Modified on: February 27th, 2023

Overview

This report provides exploratory and preliminary correlation analyses between sex hormones and T2 final hippocampal subfield volume data from the Healthy Aging Study sample that have completed the spatial navigation study.

Cleaning data steps included (T2 subfields):

  1. Filter participants that have useable T2 subfield data from scan and completed spatial navigation behavior

  2. Select sex hormone measures from when spatial study was conducted

  3. Values were already averaged together (left and right) and already corrected with TIV

For left and right subfields, they have already been corrected with TIV

Calculating Total Hippocampal Volume:

  • Sum up the averaged CA1, CA23, DG, SUB to get T2 total hippocampal volumes

  • Left and right volumes are by adding respective left and right subfields

Calculating Total MTL:

  • Sum up the averaged CA1, CA23, DG, SUB, ERC, PHC, PRC to get MTL volume

  • Left and right volumes are by adding respective left and right subfields

Sample size and age for women and men grouped by overall completion of spatial DSP with useable T2hipp data.
Sex n Mean Age SD Age
Female 33 50.15 3.09
Male 19 49.74 3.33

Above table shows the table of sample size and mean and standard deviation of age by sex for overall group who have completed spatial behavior and have a useable T2hipp scan.

Behavioral Distributions

Shapiro-Wilk’s test reveal that DSP solution index for overall and women and DSP path efficiency for women were also not normally distributed. Behavior and volume correlations will be Spearman rank

Total Hippocampal Volume

Behavioral Correlations

DSP

Wayfinding Success

All correlations were Pearson

LEFT

All correlations were Pearson

Solution Index

All correlations were Spearman except for men (Pearson).

LEFT

All correlations were Spearman except for men (Pearson).

RIGHT

All correlations were Spearman except for men (Pearson).

Path Efficiency

All correlations are Pearson except for women (Spearman)

LEFT

All correlations are Pearson except for women (Spearman)

RIGHT

All correlations are Pearson except for women (Spearman)

MTL

Behavioral Correlations

DSP

Wayfinding Success

All correlations are Pearson

LEFT

All correlations are Pearson

RIGHT

All correlations are Pearson

Solution Index

All correlations were Spearman except for men (Pearson)

LEFT

All correlations were Spearman except for men (Pearson)

RIGHT

All correlations were Spearman except for men (Pearson)

Path Efficiency

All correlations are Pearson except for women/repo (Spearman)

LEFT

All correlations are Pearson except for women/repo (Spearman)

RIGHT

All correlations are Pearson except for women/repo (Spearman)

T2 Subfield Volume

CA1

Behavioral Correlations

DSP

Wayfinding Success

All correlations were Spearman except for men (Pearson)

LEFT

All correlations were Spearman except for men (Pearson)

RIGHT

All correlations were Spearman except for men (Pearson)

Solution Index

All correlations were Spearman except for men (Pearson)

LEFT

All correlations were Spearman except for men (Pearson)

RIGHT

All correlations were Spearman except for men (Pearson)

Path Efficiency

All correlations Pearson except for women/repo (Pearson)

LEFT

All correlations Pearson except for women/repo (Pearson)

RIGHT

CA2/3

Behavioral Correlations

DSP

Wayfinding Success

All correlations are Pearson

LEFT

All correlations are Pearson

RIGHT

All correlations are Pearson

Solution Index

All correlations are Spearman except for men (Pearson)

LEFT

All correlations are Spearman except for men (Pearson)

RIGHT

All correlations are Spearman except for men (Pearson)

Path Efficiency

All correlations Pearson except for women/repo (Spearman)

LEFT

All correlations Pearson except for women/repo (Spearman)

RIGHT

All correlations Pearson except for women/repo (Spearman)

DG

Behavioral Correlations

DSP

Wayfinding Success

All correlations were Pearson

LEFT

All correlations were Pearson

RIGHT

All correlations were Pearson

Solution Index

All correlations were Spearman except for men (Pearson)

LEFT

All correlations were Spearman except for men (Pearson)

RIGHT

All correlations were Spearman except for men (Pearson)

Path Efficiency

All correlations are Pearson except for women/repo

LEFT

All correlations are Pearson except for women/repo

RIGHT

All correlations are Pearson except for women/repo

ERC

Behavioral Correlations

DSP

Wayfinding Success

All correlations are Pearson

LEFT

All correlations are Pearson

RIGHT

All correlations are Pearson

Solution Index

All correlations were Spearman except for men (Pearson)

LEFT

All correlations were Spearman except for men (Pearson)

RIGHT

All correlations were Spearman except for men (Pearson)

Path Efficiency

All correlations are Pearson except for women/repo

LEFT

All correlations are Pearson except for women/repo

RIGHT

All correlations are Pearson except for women/repo

PHC

Behavioral Correlations

DSP

Wayfinding Success

Overall and male correlations were Pearson, female and repo groups were Spearman.

LEFT

Overall and male correlations were Pearson, female and repo groups were Spearman.

RIGHT

Overall and male correlations were Pearson, female and repo groups were Spearman.

Solution Index

All correlations were Spearman except for men (Pearson)

LEFT

All correlations were Spearman except for men (Pearson)

RIGHT

All correlations were Spearman except for men (Pearson)

Path Efficiency

Overall and men are Pearson, women and repo groups are Spearman

LEFT

Overall and men are Pearson, women and repo are Spearman

RIGHT

Overall and men are Pearson, women and repo are Spearman

PRC

Behavioral Correlations

DSP

Wayfinding Success

All correlations were Pearson

LEFT

All correlations were Pearson

RIGHT

All correlations were Pearson

Solution Index

All correlations were Spearman except for men (Pearson)

LEFT

All correlations were Spearman except for men (Pearson)

RIGHT

All correlations were Spearman except for men (Pearson)

Path Efficiency

All correlations were Pearson except for women/repo

LEFT

All correlations were Pearson except for women/repo

RIGHT

All correlations were Pearson except for women/repo

SUB

Behavioral Correlations

DSP

Wayfinding Success

All correlations were Pearson

LEFT

All correlations were Pearson

RIGHT

All correlations were Pearson

Solution Index

All correlations were Spearman except for men (Pearson)

LEFT

All correlations were Spearman except for men (Pearson)

RIGHT

All correlations were Spearman except for men (Pearson)

Path Efficiency

All correlations were Pearson except for women/repo

LEFT

All correlations were Pearson except for women/repo

RIGHT

All correlations were Pearson except for women/repo

Summary

Sample included HAS participants who had a T2 hipp scan and completed spatial navigation behavior.

Total hipp Volume and MTL

  • There were no significant correlations observed for total hipp volume or MTL and navigation behaviors for DSP.

Subfields

  • DSP wayfinding success was significantly negatively correlated with average ERC volume for overall. It was also negatively correlated with average PHC volume for women.

  • DSP solution index was significantly negatively correlated with DG volume for overall and posts (right volume) and for men (average volume). It was positively correlated with right PRC volume for pres.

  • DSP path efficiency was positively correlated with average and left ERC volume for overall, women and for pres (average volume only). It was also negatively correlated with average and left PHC volume for women.